THE CUTTING-EDGE SCIENCE TO TARGET CRUCIAL DRIVERS
OF CANCER AND INFLAMMATION

Our proprietary drug discovery and development engine has identified several immune drivers that have the ability to be “tuned up” or “tuned down” to modulate the immune system, either to initiate an immune response against a tumor in cancer or to suppress an overactive immune response in inflammatory diseases.
Our lead drug candidates, FLX475 and RPT193, target the important cell surface receptor CCR4 (C-C Motif Chemokine Receptor 4). Receptors such as CCR4 bind to chemoattractant molecules called chemokines that orchestrate migration and homing of cells to specific tissues throughout the body. Chemokines specific to CCR4 are secreted from tumors and from inflamed tissues, but not from healthy tissues. Our proprietary approach is designed to prevent the recruitment of disease-promoting immune cells into tumors and inflamed tissues in order to treat cancer and inflammatory diseases.

CCR4 INHIBITION IN CANCER:
The potential to unlock antitumor immunity

In cancer, the secretion of certain chemokines from tumor cells and tumor-resident immune cells is responsible for recruitment of immunosuppressive regulatory T cell (Treg) cells to tumor sites. Treg represent a dominant pathway for downregulating the immune response, and thus may limit the effectiveness of currently available therapies such as checkpoint inhibitors. Blocking the migration of Treg has the potential to restore naturally occurring antitumor immunity as well as to synergize with a variety of both conventional and immune-based therapies, such as radiation, chemotherapy, checkpoint inhibitors, immune stimulators and adoptive T cell therapy.
Our proprietary approach is designed to enable selective restoration of the immune response within tumors without systemically depleting T cells or broadly suppressing the immune system, a side effect experienced with existing CCR4 therapies. We believe that the inhibition of CCR4 has the potential to bring therapeutic benefit to patients across a wide spectrum of tumors in a manner similar to other immuno-oncology therapies that have been shown to be effective against multiple tumor types, while also potentially deepening and/or broadening clinical responses to these therapies.

CCR4 INHIBITION IN INFLAMMATORY DISEASE:
The capacity to “down regulate” the inflammatory response

In inflammatory diseases, chemokines recruit helper T type 2 (Th2) cells to inflamed tissues. Once Th2 cells enter tissues such as the skin or the airways in the lung, they secrete proteins known to drive the inflammatory response. In atopic dermatitis, there are higher levels of these inflammatory ligands compared with healthy humans and these ligands also correlate with the severity of disease.
We believe that by inhibiting CCR4, RPT193 (our novel drug candidate) has the potential to bring therapeutic benefit to patients across a broad spectrum of inflammatory diseases, including atopic dermatitis, asthma, chronic urticaria, chronic rhinosinusitis or rhinoconjunctivitis, inflammatory conjunctivitis and eosinophilic esophagitis.

HPK1 INHIBITION:
The key to unleashing tumor-specific T cell responses

Hematopoietic progenitor kinase 1 (HPK1) reduces the T cell response to tumor cells by blocking the T cell receptor (TCR) signaling needed to mount an effective immune response against tumor cells. We believe that blocking HPK1 activity can enhance tumor-specific T cells and bring therapeutic benefit to patients with many different tumor types, either as monotherapy or in combination with other treatment modalities, including checkpoint inhibitors.